> But in people with diabetes, this sensing system is dysfunctional, and the liver releases glucose even when blood levels are already high, causing a host of health problems.
I am pretty sure, that the dysfunctional glucose sensing and inappropriate liver glucose release are consequences and complications of diabetes, not the primary causes. Diabetes (Type 2) is primarily caused by insulin resistance combined with progressive beta cell dysfunction.
Therefore, treating the liver to treat diabetes seems .... weird?
As an analogy, when my driveway is covered in snow and ice, the root cause is precipitation. But my immediate need is to get my car out, so I shovel the drive.
Yes, treating symptoms is not the ideal, but if you can fix the immediate need of getting blood sugar down, that is still helpful.
In your story, your driveway was designed to be shoveled like the body is designed to deal with small amounts of sugar.
Let's say we had a particularly bad winter that required the use of power tools, which had the effect of damaging the driveway. Your body on diabetes is like a damaged driveway.
At some point you'll need to fix the damaged driveway. It will require a change in lifestyle while the driveway is being fixed, and perhaps even a change SOP's to reduce the risk of future damage.
Most people never give up on the power tools (supplemental insulin). Most doctors don't know any better.
Your analogy doesn't really apply to anyone with type 1 diabetes, which is an autoimmune disorder and roughly 10% of all diabetes cases. A lifestyle change cannot fix type 1 diabetes.
Additionally, partial remission in type 2 diabetes has a success rate of just 0.007% per 5 year post-remission cohort. The idea that a lifestyle change can "fix the damaged driveway" is essentially a statistical anomaly - it's not grounded in evidential standards has yet to be proven.
Does it matter? A success rate of 0.007% is practically a statistical error. It signifies that the method is not feasible regardless of individual factors.
You're right. But they explicitly wrote "we examined the potential of FUS as a treatment for diabetes". So they are discussing a treatment, not just symptom relief
There is a lot of research pointing to the duodenum being damaged and not playing it role correctly. It is essentially the signaler to the pancreas and gall bladder and liver to release All The Things! There have even been some studies around a new approach that resurfaces the duodenum with a hot water balloon that brings back proper function, known as Duodenal Mucosal Resurfacing (DMR).
While reading this article, I kept thinking about one thing: are we moving into an era where the nervous system becomes the new kind of medicine?
If ultrasound can truly influence the neural signals between the brain and internal organs in a safe and precise way, maybe we won't need to treat individual organs in isolation anymore.
I know I'm meant to be thinking, "wow this is so awesome, the body is amazing!" but all I can think about is the future of war crimes. And I don't know if that says more about what goes on inside my head or what is happening outside of it.
> One day, an AI system might be able to guide at-home users as they place a wearable device on their body and trigger the stimulation.
How would that work? Do we even have a reliable way of detecting localized places of internal inflammation? The article mentions ultrasound imaging, but this is beginning to sound a lot like a "if all you've got is a hammer" type thing.
What about other localized inflammatory conditions, such as asthma?
It's not quite "we only have hammers". It's very much "everyone is now using rubber-handled sledgehammers, so we had better mention that we could use rubber-handled sledgehammers, too!"
But functionally they have the same effect - ie they cause the subject to vibrate and heat. I think it's fair to say they are similar functionally... Or do you disagree?
These two are as diffent as you can get. Electromagnetic waves mostly ignore you, except some atoms. Sounds waves propagate through you, and will cause some organs to resonate more.
Consciousness is essentially made of brain waves, and it's the 3D positions of the EM fields which is at the core of it. So it makes sense that jiggling around brain matter to where it is in frequencies that resonate with the same frequencies building consciousness then we can alter conscious state.
It was recently discovered that when listening to music your brain waves sync up to the same frequencies, which I had predicted for a long time. This means the "computational model" (i.e. synapses and neural nets) theory of consciousness is mostly wrong.
> But in people with diabetes, this sensing system is dysfunctional, and the liver releases glucose even when blood levels are already high, causing a host of health problems.
I am pretty sure, that the dysfunctional glucose sensing and inappropriate liver glucose release are consequences and complications of diabetes, not the primary causes. Diabetes (Type 2) is primarily caused by insulin resistance combined with progressive beta cell dysfunction.
Therefore, treating the liver to treat diabetes seems .... weird?
As an analogy, when my driveway is covered in snow and ice, the root cause is precipitation. But my immediate need is to get my car out, so I shovel the drive.
Yes, treating symptoms is not the ideal, but if you can fix the immediate need of getting blood sugar down, that is still helpful.
In your story, your driveway was designed to be shoveled like the body is designed to deal with small amounts of sugar.
Let's say we had a particularly bad winter that required the use of power tools, which had the effect of damaging the driveway. Your body on diabetes is like a damaged driveway.
At some point you'll need to fix the damaged driveway. It will require a change in lifestyle while the driveway is being fixed, and perhaps even a change SOP's to reduce the risk of future damage.
Most people never give up on the power tools (supplemental insulin). Most doctors don't know any better.
Your analogy doesn't really apply to anyone with type 1 diabetes, which is an autoimmune disorder and roughly 10% of all diabetes cases. A lifestyle change cannot fix type 1 diabetes.
Additionally, partial remission in type 2 diabetes has a success rate of just 0.007% per 5 year post-remission cohort. The idea that a lifestyle change can "fix the damaged driveway" is essentially a statistical anomaly - it's not grounded in evidential standards has yet to be proven.
What factors contribute to the poor success rate?
Does it matter? A success rate of 0.007% is practically a statistical error. It signifies that the method is not feasible regardless of individual factors.
I understand the treatment to address those secondary consequences and complications, not the primary causes of diabetes.
You're right. But they explicitly wrote "we examined the potential of FUS as a treatment for diabetes". So they are discussing a treatment, not just symptom relief
"Medical treatment" definitely doesn't always mean dealing with the root cause. As you've learned.
Splinting a leg is treatment, but it has nothing to do with not drinking before driving.
Are you confusing the term "treatment" for the term "cure"? Symptom relief is a type of treatment.
There is a lot of research pointing to the duodenum being damaged and not playing it role correctly. It is essentially the signaler to the pancreas and gall bladder and liver to release All The Things! There have even been some studies around a new approach that resurfaces the duodenum with a hot water balloon that brings back proper function, known as Duodenal Mucosal Resurfacing (DMR).
You are talking about more like reversing the disease
While reading this article, I kept thinking about one thing: are we moving into an era where the nervous system becomes the new kind of medicine? If ultrasound can truly influence the neural signals between the brain and internal organs in a safe and precise way, maybe we won't need to treat individual organs in isolation anymore.
How does the frequency and amplitude of something used for this approach compare to that used for routine fetal imaging?
The difference is that they use a focused beam here.
I know I'm meant to be thinking, "wow this is so awesome, the body is amazing!" but all I can think about is the future of war crimes. And I don't know if that says more about what goes on inside my head or what is happening outside of it.
A nontrivial plot point in Kim Stanley Robinson's "Green Mars" (1993)
Wow, why don't I remember that. Guess it's time to pull that down off the shelf again.
That was my first thought as well. Reminds me of the infamous Havana syndrome.
> One day, an AI system might be able to guide at-home users as they place a wearable device on their body and trigger the stimulation.
How would that work? Do we even have a reliable way of detecting localized places of internal inflammation? The article mentions ultrasound imaging, but this is beginning to sound a lot like a "if all you've got is a hammer" type thing.
What about other localized inflammatory conditions, such as asthma?
It's not quite "we only have hammers". It's very much "everyone is now using rubber-handled sledgehammers, so we had better mention that we could use rubber-handled sledgehammers, too!"
Is there much of a functional difference between 'ultrasound' and 'microwaves'? Both seem to impact cells at a distance, causing them to vibrate.
Microwave is high frequency light (300Mhz-300GHz).
Ultrasound is high frequency sound/vibration (+20kHz).
Light you can't see, sound you can't hear... Ok.
But functionally they have the same effect - ie they cause the subject to vibrate and heat. I think it's fair to say they are similar functionally... Or do you disagree?
There are many ways to transfer kinetic energy.
These two are as diffent as you can get. Electromagnetic waves mostly ignore you, except some atoms. Sounds waves propagate through you, and will cause some organs to resonate more.
One unifying thing is the waves.
Consciousness is essentially made of brain waves, and it's the 3D positions of the EM fields which is at the core of it. So it makes sense that jiggling around brain matter to where it is in frequencies that resonate with the same frequencies building consciousness then we can alter conscious state.
It was recently discovered that when listening to music your brain waves sync up to the same frequencies, which I had predicted for a long time. This means the "computational model" (i.e. synapses and neural nets) theory of consciousness is mostly wrong.
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